Chiaki Isobe Selected Research

Coenzymes (Enzyme Cofactors)

3/2010	Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the CSF of patients with Alzheimer's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process.
1/2010	Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process.
1/2009	Increase in the oxidized/total coenzyme Q-10 ratio in the cerebrospinal fluid of Alzheimer's disease patients.
4/2007	Increase of oxidized/total coenzyme Q-10 ratio in cerebrospinal fluid in patients with Parkinson's disease.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Chiaki Isobe Research Topics

Disease

5	Parkinson Disease (Parkinson's Disease) 06/2010 - 01/2003
5	Alzheimer Disease (Alzheimer's Disease) 03/2010 - 11/2002
1	Epilepsy (Aura) 11/2010
1	Migraine Disorders (Migraine) 11/2010
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2010
1	Lacunar Stroke 12/2009
1	Stroke (Strokes) 12/2009
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2005

Drug/Important Bio-Agent (IBA)

4	HomocysteineIBA 11/2010 - 08/2005
4	Coenzymes (Enzyme Cofactors)IBA 03/2010 - 04/2007
3	RNA (Ribonucleic Acid)IBA 01/2009 - 11/2002
2	8-Hydroxy-2'-DeoxyguanosineIBA 03/2010 - 01/2010
2	8-hydroxyguanosineIBA 01/2003 - 11/2002
1	Methionine (L-Methionine)FDA Link 06/2010
1	Levodopa (L Dopa)FDA LinkGeneric 06/2010
1	dimethylarginineIBA 01/2010
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2010
1	Free RadicalsIBA 12/2009
1	Tyrosine (L-Tyrosine)FDA Link 12/2009
1	Free Radical ScavengersIBA 12/2009
1	3-nitrotyrosineIBA 12/2009

Therapy/Procedure

1	Aftercare (After-Treatment) 06/2010
1	Therapeutics 06/2010